1. 1.
1) Ҿ Ǵ ʴ´.
2) Ӻ Ǵ ӽϰ ɼ ִ dz ¾ƿ ɼ Ƿ μų ȴ. õǾ ֱ , ų μ ʾҴٸ ÿ Ȱ а ִ.
3) к
dz 5mg ȯڿ , Ǿ, ̺ٴ Ǽ ڻ к Ǿ. ȯڸ ϰ, ȯڿ ̷ ϴ Ƿ ϵ ؾ Ѵ.
2. ȯڿ .2. ȯڿ .
1) Ǵ п ι ȯ
2) Ǵ Ҿ
3) Ӻ Ǵ ӽϰ ɼ ִ
3. ȯڿ .3. ȯڿ .
4. ̻4. ̻
1) ༺ ϰ ̻ Ϲ ϰ Ͻ̾.
2) ܱ ӻ
4Ⱓ ӻ(PLESS, Proscar LongTerm Efficacy and Safety Study) ġḦ 1,524 ȯڿ ġḦ 1,516 ȯڿ 4 ģ ǽϿ. ġ 3.7 %(57 ȯ), ġ 2.1 % (32 ȯ) ɰ ̻ ġḦ ߴϿ, ϰ ̻ ɰ ̻̾. 4Ⱓ ӻ迡 ຸ Ͽ 1 % ̻̾ ӻ迬ڿ õǾ ɼ ְų, Ƹ õǾ ְų, и õǾ ִٰ ֵ ̻ ǥ1 Ҵ. ӻ 2 4 ߱, 尨, ̰ .
ǥ1. ̻
| 1(%) | 2 4(%) |
| (n=1,524) | (n=1,516) | (n=1,524) | (n=1,516) |
߱ | 8.1 | 3.7 | 5.1 | 5.1 |
尨 | 6.4 | 3.4 | 2.6 | 2.6 |
װ | 3.7 | 0.8 | 1.5 | 0.5 |
| 0.8 | 0.1 | 0.2 | 0.1 |
| 0.5 | 0.1 | 1.8 | 1.1 |
| 0.4 | 0.1 | 0.7 | 0.3 |
| 0.5 | 0.2 | 0.5 | 0.1 |
3) 뿡 ڷ
3,047 ȯڸ 4 6Ⱓ 缺 ӻ迡, 5 mg 4 Ͽ, ౺ 缺 ʾҴ. 3,040 ȯڸ 4Ⱓ ӻ迡 ౺ 2 Ͽ 5 mg ʾҴ. 18,882 7Ⱓ ӻ(Prostate Cancer Prevention Trial, PCPT) ౺ 1 Ͽ. Ͽ ִ. Ⱓ Ż ü ˷ ʴ.
PCPT ӻ ˻翡 ̰ Ư(Prostate Specific Antigen, PSA) ġ 3.0 ng/mL 55 ̻ 18,882 7Ⱓ , ߸Ͱ, ӻ̾. 5 mg Ǵ 1 1ȸ Ҵ. ȯڵ ˻ PSA , ü˻ PSA µǰų ˻翡 ӻ Ͽ. (1.1 %) (1.8 %) Gleason 8 10 Ҵ. ٸ 5-ȯȿ (Ÿ) 4Ⱓ ӻ迡 Gleason 8 10 Ͽ Ǿ(1 % Ÿ vs. 0.5 %). 5 mg ȯڿ ӻ ͼ ʾҴ.
4) ܱ
/Ǵ 뷮 ̻ ߰ Ǿ. ̻ Ư αܿ ڹ ̱ , ŷڼ ְ ϰų ΰ踦 Ȯϴ Ϲ ʴ.
(1) 鿪 : , ε巯 (Լ, , â ) ι
(2) ٰݰ : , ٹ
(3) Ű : , ڻ, ߴ ӵǴ 尨, Ҿ
(4) İ : ȯ ; ; ߴ ӵǴ (߱, ) ; /Ǵ . dz ߴ ȭ Ȥ Ǿ. ;
(5) (Ӿ), ,
5)
6⵿ 3,675 ǽ ̻ ΰ 107 124(3.37 %) Ǿ, ΰ谡 ִ (Ӿ), ߱, 尨, ( ), , , ι, , ̾.
(1) ȭ : ȭҷ, , (Ӿ), 7(0.19 %)
(2) ı : ߱, 尨, () 102(2.78 %)
(3) Ǻ : , 2(0.05 %)
(4) : , ι, , ° 6(0.16 %)
(5) Ÿ : , ̿, ̻ 7(0.19 %)
5. Ϲ 5. Ϲ
1) ȿ ϰ Ÿ Ƿ ٷ ܷ ȯڳ ɰϰ ȯڴ ȯ DZ ˻ƾ Ѵ.
2) ǻ ġḦ ϱ ռ , , ȯ, 强 汤 Ǵ 缺(BPH) ٸ Űȯ Ȯϱ ǽؾ ϸ, ȯڿ ǰ о ϰ ó ѹ о Ͽ ȯڵ õ ֽ νϵ Ѵ.
3) ǻ ġϴ Ϻ ȯڿ ִٴ ȯڿ ˷ Ѵ. ̷ Ұ ϴ ġḦ ȯڿ ߱ 尨 ִ.
4) ˻翡 ̰ PSA ġ 3.0 ng/mL 55 ̻ 7Ⱓ 1 5 mg PCPT ӻ迡 Gleason 8 10 輺 Ǿ(dz 1.8 % vs. 1.1 %).ٸ 5-ȯȿ (Ÿ)(1 % Ÿ vs. 0.5 % ) 4Ⱓ ӻ迡 Ǿ. 5-ȯȿ 輺 ų , Ǹ ҽŰ 5-ȯȿ ȿ , ̷ ġ ٸ ε Ȯ ʾҴ.
6. ȣۿ6. ȣۿ
1) õ ȣۿ ˷ .
2) CYP-450 ȿҰ迡 ġ Ƿ ̷ Ǵ , , ۸긮, ĸ, ʸ, ƼǸ ȣۿ Ÿ ʴ´.
3) ACE, , Ÿ, Įä, 强꿰, ̴, H2, HMG CoAȯȿҾ, ̵强ҿ(NSAIDS), , ӻ ̻ Ÿ ʴ´.
7. Ӻ ο 7. Ӻ ο
1) Ӻγ ӽϰ ɼ ִ Ѵ. Ӻΰ ¾ ܺλı ʷ ִ(5-ȯȿ 佺 ̵佺 ȯǴ Ѵ). ӽ ߿ ߰ų Ǵ ϴ ߿ ӽ Ǹ ӽſ ¾ƿ 輺 ˷־ Ѵ. Ʈ 迡 ӽ ߿ 뷮 Ͽ ƻ α ʷϿ.
2) μ Ǿ Ӻ ¾ ܺλı ʷ Ƿ μ Ӻγ ӽ ɼ ִ ؼ ȴ. , ų μ ʾҴٸ Ǿ ־ ÿ ּп ʴ´.
3) ӻ迡 5 mg/day 6 24 ҷ dz尡 ȸǾ. ӽ ġḦ ȯ ǰ Ǵ dz rhesus 迡 ¾ no-effect level شϴ dz 50 100 뷮̴.
4) δ Ȯ ο ʴ´.
8. Ҿƿ 8. Ҿƿ
9. ڿ 9. ڿ
ܱ ӻ(PLESS) 65 ̻ 1,480̾ 75 ̻ 105̾. ڿ ڰ ȿ ̰ ʾ, ٸ ӻ 迡 ڿ ȯڰ ̰ . ڿ 뷮 ʿ ʴ.
10. ӻ˻ġ 10. ӻ˻ġ
1) ġḦ ȯڿ ӻ ȿ ʰ ִ. ӻ迡 Ư(PSA) ġ PSA 缺 ȯڸ Ͽ. ̷ BPHӻ迡, ȭŰ ʴ Ÿ. , ü ߺ ġḦ ȯ Ǵ ġḦ ȯڿ ̰ .
Ͽ 缺 ȯ û PSA 뷫 50 % ҽŲ. ̷ Ҵ ȯڿ ֱ , ü PSAġ ϴ. PLESS ӻ 3,000 ̻ ȯڷκ PSA ڷ м, 6 ̻ ġḦ ȯ PSAġ ġḦ 2 ؾ Ѵٴ ȮεǾ. ̷ PSA м ΰ Ư̵ ǰ, ܴɷ ִ.
ġḦ ȯ PSA ġ ġῡ ϴ Ͽ DZ ؾ Ѵ.
PSAġ ( PSA PSA ) ϰ ʴ´. PSA PSA Ͽ ״ ȴ. ܿ PSAġ Ȱϴ , ġ ʿϴ.
2) 缺 ȯڿ, Ƽ, Ʈ, ζƾ, ڱ ȣ Ǵ ƼϽ ȯ ʾҴ. ( ݷ, еܹ, еܹ, Ʈ۸) Ǵ е ӻ ߿ ȿ ʾҴ. ϴ ȯڿ Ȳüȣ(LH) ڱȣ(FSH) 10 % ϴ Ǿ, ̳. ǰ ڿ ġ ڱȣ ڿ LH FSH ȭŰ ʴµ, ̴ ûϺΡϼüȯ ûѴ.
ǰ ڿ Ķ ϱ 24ְ ġ , , , pH ӻ ʾҴ. ü ҵǾ 0.6 mL(22.1 %) Ұ Ǿ. ̵ Ķʹ ȿ ־ ġḦ ߴ ҸDZ Ͽ 84 · ȸǾ.
11. óġ11. óġ
1) ÿ Ǵ Ư ġ .
2) 400 mg ȸϰų 3 1 80 mg ݺ ȯڿ ̻ Ÿ ʾҴ.
12. ǻ12. ǻ
1) ʴ Ѵ.
2) ٸ ٲپ ִ ǰų ǰ 鿡 ٶ Ƿ ̸ Ѵ.